A natural genetic variant of granzyme B confers lethality to a common viral infection.
Many immune response genes are highly polymorphic, consistent with the selective pressure imposed by pathogens over evolutionary time, and the need to balance infection control with the risk of auto-immunity. Epidemiological and genomic studies have identified many genetic variants that confer susce...
Main Authors: | Christopher E Andoniou, Vivien R Sutton, Matthew E Wikstrom, Peter Fleming, Kevin Y T Thia, Antony Y Matthews, Dion Kaiserman, Iona S Schuster, Jerome D Coudert, Preethi Eldi, Geeta Chaudhri, Gunasegaran Karupiah, Phillip I Bird, Joseph A Trapani, Mariapia A Degli-Esposti |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-12-01
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Series: | PLoS Pathogens |
Online Access: | https://doi.org/10.1371/journal.ppat.1004526 |
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