Cell Wall Proteomics Reveal Phenotypic Adaption of Drug-Resistant Mycobacterium smegmatis to Subinhibitory Rifampicin Exposure

Cell Wall Proteomics Reveal Phenotypic Adaption of Drug-Resistant Mycobacterium smegmatis to Subinhibitory Rifampicin Exposure

Despite the availability of effective drug treatment, Mycobacterium tuberculosis (Mtb), the causative agent of TB disease, kills ~1. 5 million people annually, and the rising prevalence of drug resistance increasingly threatens to worsen this plight. We previously showed that sublethal exposure to t...

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Bibliographic Details
Main Authors: Alexander D. Giddey, Tariq A. Ganief, Naadir Ganief, Anastasia Koch, Digby F. Warner, Nelson C. Soares, Jonathan M. Blackburn
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Medicine
Subjects:
mass spectrometry
proteomics
rifampicin
Mycobacterium smegmatis
phenotypic adaption
ABC transporters
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2021.723667/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2021.723667/full

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