Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans

Doxorubicin-Induced Cardiotoxicity in Collaborative Cross (CC) Mice Recapitulates Individual Cardiotoxicity in Humans

Anthracyclines cause progressive cardiotoxicity whose ultimate severity is individual to the patient. Genetic determinants contributing to this variation are difficult to study using current mouse models. Our objective was to determine whether a spectrum of anthracycline induced cardiac disease can...

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Bibliographic Details
Main Authors: Caroline J. Zeiss, Daniel M. Gatti, Olga Toro-Salazar, Crystal Davis, Cathleen M. Lutz, Francis Spinale, Timothy Stearns, Milena B. Furtado, Gary A. Churchill
Format: Article
Language:English
Published: Oxford University Press 2019-08-01
Series:G3: Genes, Genomes, Genetics
Subjects:
Anthracyclines
cardiotoxicity
biomarkers
fibrosis
mouse
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400232

Internet

http://g3journal.org/lookup/doi/10.1534/g3.119.400232

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