High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer.

High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer.

Cancer is caused by somatic DNA alterations such as gene point mutations, DNA copy number aberrations (CNA) and structural variants (SVs). Genome-wide analyses of SVs in large sample series with well-documented clinical information are still scarce. Consequently, the impact of SVs on carcinogenesis...

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Bibliographic Details
Main Authors: Evert van den Broek, Maurits J J Dijkstra, Oscar Krijgsman, Daoud Sie, Josien C Haan, Joleen J H Traets, Mark A van de Wiel, Iris D Nagtegaal, Cornelis J A Punt, Beatriz Carvalho, Bauke Ylstra, Sanne Abeln, Gerrit A Meijer, Remond J A Fijneman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4574474?pdf=render

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http://europepmc.org/articles/PMC4574474?pdf=render

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