Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases.

Design, synthesis and characterization of a highly effective inhibitor for analog-sensitive (as) kinases.

Highly selective, cell-permeable and fast-acting inhibitors of individual kinases are sought-after as tools for studying the cellular function of kinases in real time. A combination of small molecule synthesis and protein mutagenesis, identified a highly potent inhibitor (1-Isopropyl-3-(phenylethyny...

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Bibliographic Details
Main Authors: Michael Klein, Montse Morillas, Alexandre Vendrell, Lars Brive, Marinella Gebbia, Iain M Wallace, Guri Giaever, Corey Nislow, Francesc Posas, Morten Grøtli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3117834?pdf=render

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http://europepmc.org/articles/PMC3117834?pdf=render

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