Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic Study of Tebipenem Pivoxil Granules After Single Escalating Oral Dose in Healthy Chinese Volunteers

Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic Study of Tebipenem Pivoxil Granules After Single Escalating Oral Dose in Healthy Chinese Volunteers

Tebipenem pivoxil (TBPM-PI), an oral carbapenem antibiotic, has shown special advantages in pediatric infections and was in urgent need in China. Although pharmacokinetics, urinary excretion, and metabolite information of its active form tebipenem (TBPM) has been reported, ethnic differences may exi...

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Bibliographic Details
Main Authors: Zeyun Li, Mei Su, Weiyan Cheng, Jueyu Xia, Shuaibing Liu, Ruijuan Liu, Suke Sun, Luyao Feng, Xueya Zhu, Xiaojian Zhang, Xin Tian, Lingbo Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
tebipenem pivoxil
pharmacokinetics
urinary excretion
metabolites
pharmaco-metabolomics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.696165/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.696165/full

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