A phase I–II controlled randomized trial using a promising novel cell-free formulation for articular cartilage regeneration as treatment of severe osteoarthritis of the knee

A phase I–II controlled randomized trial using a promising novel cell-free formulation for articular cartilage regeneration as treatment of severe osteoarthritis of the knee

Abstract Background A promising novel cell-free bioactive formulation for articular cartilage regeneration, called BIOF2, has recently been tested in pre-clinical trials. The aim of the present study was to evaluate the efficacy and safety of BIOF2 for intra-articular application in patients with se...

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Bibliographic Details
Main Authors: Ivan Delgado-Enciso, Juan Paz-Garcia, Jose Valtierra-Alvarez, Jorge Preciado-Ramirez, Roman Almeida-Trinidad, Jose Guzman-Esquivel, Martha A. Mendoza-Hernandez, Alberto Garcia-Vega, Alejandro D. Soriano-Hernandez, Jose L. Cortes-Bazan, Hector R. Galvan-Salazar, Ariana Cabrera-Licona, Iram P. Rodriguez-Sanchez, Margarita L. Martinez-Fierro, Josuel Delgado-Enciso, Brenda Paz-Michel
Format: Article
Language:English
Published: BMC 2018-10-01
Series:European Journal of Medical Research
Subjects:
Osteoarthritis
Knee
Treatment
Cartilage regeneration
Chondrocytes
Stem cell
Online Access:http://link.springer.com/article/10.1186/s40001-018-0349-2

Internet

http://link.springer.com/article/10.1186/s40001-018-0349-2

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