Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo [version 1; referees: 2 approved, 1 approved with reservations]

Background: Pseudomonas species are adapted to evade innate immune responses and can persist at sites of relative tissue hypoxia, including the mucus-plugged airways of patients with cystic fibrosis and bronchiectasis.  The ability of these bacteria to directly sense and respond to changes in local...

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Bibliographic Details
Main Authors: Rebecca S. Dickinson, Fiona Murphy, Catherine Doherty, Sam Williams, Ananda Mirchandani, Joseph Willson, John S. Scotti, Gail Preston, Christopher J. Schofield, Moira K.B. Whyte, Sarah R. Walmsley
Format: Article
Language:English
Published: Wellcome 2017-10-01
Series:Wellcome Open Research
Subjects:
Online Access:https://wellcomeopenresearch.org/articles/2-104/v1