Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage

Single-Cell Transcriptome Analysis of Colon Cancer Cell Response to 5-Fluorouracil-Induced DNA Damage

Summary: DNA damage often induces heterogeneous cell-fate responses, such as cell-cycle arrest and apoptosis. Through single-cell RNA sequencing (scRNA-seq), we characterize the transcriptome response of cultured colon cancer cell lines to 5-fluorouracil (5FU)-induced DNA damage. After 5FU treatment...

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Bibliographic Details
Main Authors: Sung Rye Park, Sim Namkoong, Leon Friesen, Chun-Seok Cho, Zac Zezhi Zhang, Yu-Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, Jun Hee Lee
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
DNA damage
5-fluorouracil
single cell
scRNA-seq
apoptosis
cell cycle checkpoint
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720310627

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http://www.sciencedirect.com/science/article/pii/S2211124720310627

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