Human ApoA-I Overexpression Enhances Macrophage-Specific Reverse Cholesterol Transport but Fails to Prevent Inherited Diabesity in Mice

Human ApoA-I Overexpression Enhances Macrophage-Specific Reverse Cholesterol Transport but Fails to Prevent Inherited Diabesity in Mice

Human apolipoprotein A-I (hApoA-I) overexpression improves high-density lipoprotein (HDL) function and the metabolic complications of obesity. We used a mouse model of diabesity, the db/db mouse, to examine the effects of hApoA-I on the two main functional properties of HDL, i.e., macrophage-specifi...

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Bibliographic Details
Main Authors: Karen Alejandra Méndez-Lara, Núria Farré, David Santos, Andrea Rivas-Urbina, Jari Metso, José Luis Sánchez-Quesada, Vicenta Llorente-Cortes, Teresa L. Errico, Enrique Lerma, Matti Jauhiainen, Jesús M. Martín-Campos, Núria Alonso, Joan Carles Escolà-Gil, Francisco Blanco-Vaca, Josep Julve
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:International Journal of Molecular Sciences
Subjects:
HDL functions
reverse cholesterol transport
metabolic syndrome
obesity
hepatic steatosis
Online Access:https://www.mdpi.com/1422-0067/20/3/655

Internet

https://www.mdpi.com/1422-0067/20/3/655

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