Positive allosteric modulation of mGluR5 accelerates extinction learning but not relearning following methamphetamine self-administration

Positive allosteric modulation of mGluR5 accelerates extinction learning but not relearning following methamphetamine self-administration

Recent studies have implicated glutamate neurotransmission as an important substrate for the extinction of conditioned behaviors, including responding for drug reinforcement. Positive allosteric modulation of the type-5 metabotropic glutamate receptor (mGluR5) in particular has emerged as a treatmen...

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Bibliographic Details
Main Authors: Peter R Kufahl, Lauren E Hood, Natali E Nemirovsky, Piroska eBarabas, Casey eHalstengard, Angel eVilla, Elisabeth eMoore, Lucas R Watterson, M Foster eOlive
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Pharmacology
Subjects:
Methamphetamine
reinstatement
cognitive enhancement
Extinction learning
mGluR5
positive allosteric modulator
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00194/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2012.00194/full

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