CXCL12 induces connective tissue growth factor expression in human lung fibroblasts through the Rac1/ERK, JNK, and AP-1 pathways.

CXCL12 induces connective tissue growth factor expression in human lung fibroblasts through the Rac1/ERK, JNK, and AP-1 pathways.

CXCL12 (stromal cell-derived factor-1, SDF-1) is a potent chemokine for homing of CXCR4+ fibrocytes to injury sites of lung tissue, which contributes to pulmonary fibrosis. Overexpression of connective tissue growth factor (CTGF) plays a critical role in pulmonary fibrosis. In this study, we investi...

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Bibliographic Details
Main Authors: Chien-Huang Lin, Chung-Huang Shih, Chih-Chieh Tseng, Chung-Chi Yu, Yuan-Jhih Tsai, Mauo-Ying Bien, Bing-Chang Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25121739/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25121739/?tool=EBI

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