Characterization of the structural and functional determinants of MANF/CDNF in Drosophila in vivo model.

Characterization of the structural and functional determinants of MANF/CDNF in Drosophila in vivo model.

Mammalian MANF and CDNF proteins are evolutionarily conserved neurotrophic factors that can protect and repair mammalian dopaminergic neurons in vivo. In Drosophila, the sole MANF protein (DmManf) is needed for the maintenance of dopaminergic neurites and dopamine levels. Although both secreted and...

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Bibliographic Details
Main Authors: Riitta Lindström, Päivi Lindholm, Jukka Kallijärvi, Li-Ying Yu, T Petteri Piepponen, Urmas Arumäe, Mart Saarma, Tapio I Heino
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3760817?pdf=render

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http://europepmc.org/articles/PMC3760817?pdf=render

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