Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms

Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms

Abstract Abnormal synaptic formation and signaling is one of the key molecular features of autism spectrum disorders (ASD). Cortactin binding protein 2 (CTTNBP2), an ASD-linked gene, is known to regulate the subcellular distribution of synaptic proteins, such as cortactin, thereby controlling dendri...

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Bibliographic Details
Main Authors: Pu-Yun Shih, Bing-Yuan Hsieh, Ching-Yen Tsai, Chiu-An Lo, Brian E. Chen, Yi-Ping Hsueh
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Acta Neuropathologica Communications
Subjects:
Autism spectrum disorder
Cortactin
Dendritic spine formation
F-actin
Microtubule
Online Access:http://link.springer.com/article/10.1186/s40478-020-01053-x

Internet

http://link.springer.com/article/10.1186/s40478-020-01053-x

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