The Transcription Factor Foxc1 Promotes Osteogenesis by Directly Regulating Runx2 in Response of Intermittent Parathyroid Hormone (1–34) Treatment

The Transcription Factor Foxc1 Promotes Osteogenesis by Directly Regulating Runx2 in Response of Intermittent Parathyroid Hormone (1–34) Treatment

Parathyroid hormone (PTH) is crucial for bone remodeling. Intermittent PTH (1–34) administration stimulates osteogenesis and promotes bone formation; however, the possible targets and underlying mechanisms still remain unclear. In this study, functional links between PTH and Foxc1, a transcription f...

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Bibliographic Details
Main Authors: Ningjuan Ouyang, Hongliang Li, Minjiao Wang, Hongzhou Shen, Jiawen Si, Guofang Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
parathyroid hormone
Foxc1
Runx2
osteogenic differentiation
bone regeneration
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00592/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00592/full

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