The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma

The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma

Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are largely unknown, especially in embryonal rhabdomyosarcoma (ERMS)—a common pediatric cancer of muscle. Here, we used a zebrafish tr...

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Bibliographic Details
Main Authors: Myron S. Ignatius, Madeline N. Hayes, Riadh Lobbardi, Eleanor Y. Chen, Karin M. McCarthy, Prethish Sreenivas, Zainab Motala, Adam D. Durbin, Aleksey Molodtsov, Sophia Reeder, Alexander Jin, Sivasish Sindiri, Brian C. Beleyea, Deepak Bhere, Matthew S. Alexander, Khalid Shah, Charles Keller, Corinne M. Linardic, Petur G. Nielsen, David Malkin, Javed Khan, David M. Langenau
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
rhabdomyosarcoma
muscle
SNAI1
NOTCH1
MEF2C
tumor propagating cells
de-differentiation
self-renewal
zebrafish
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307180

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http://www.sciencedirect.com/science/article/pii/S2211124717307180

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