Vaginal Heparan Sulfate Linked to Neutrophil Dysfunction in the Acute Inflammatory Response Associated with Experimental Vulvovaginal Candidiasis

Despite acute inflammation by polymorphonuclear neutrophils (PMNs) during vulvovaginal candidiasis (VVC), clearance of Candida fails to occur. The purpose of this study was to uncover the mechanism of vaginal PMN dysfunction. Designs included assessing PMN migration, proinflammatory mediators, and t...

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Bibliographic Details
Main Authors: Junko Yano, Mairi C. Noverr, Paul L. Fidel, Liise-anne Pirofski
Format: Article
Language:English
Published: American Society for Microbiology 2017-03-01
Series:mBio
Online Access:http://mbio.asm.org/cgi/content/full/8/2/e00211-17