One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines

One Step Regioselective Synthesis of 5-Aminoisoxazoles from Nitrile Oxides and α-Cyanoenamines

The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be isolated.

Bibliographic Details
Main Authors: Aïcha Derdour, Michel Vaultier, Amar Saad
Format: Article
Language:English
Published: MDPI AG 2004-06-01
Series:Molecules
Subjects:
1-Cyanoenamines
nitrile oxides
1
3-dipolar cycloaddition
5-amino- isoxazoles.
Online Access:http://www.mdpi.com/1420-3049/9/7/527/

Internet

http://www.mdpi.com/1420-3049/9/7/527/

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