A Benziodoxole-Based Hypervalent Iodine(III) Compound Functioning as a Peptide Coupling Reagent

A Benziodoxole-Based Hypervalent Iodine(III) Compound Functioning as a Peptide Coupling Reagent

1-Benzoyloxy-1,2-benziodoxol-3-(1H)-one (IBA-OBz), a readily available and bench stable benziodoxole-based iodine(III) reagent, can be employed for the synthesis of dipeptides from various standard and sterically hindered amino acids in the presence of (4-MeOC6H4)3P. The combined system of IBA-OBz/(...

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Bibliographic Details
Main Authors: Li-Jun Qiu, Dan Liu, Ke Zheng, Ming-Tao Zhang, Chi Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Chemistry
Subjects:
peptide
IBA-OBz
hypervalent iodine(III) reagent
solid-phase peptide synthesis (SPPS)
DFT calculations
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00183/full

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https://www.frontiersin.org/article/10.3389/fchem.2020.00183/full

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