The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle.

The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle.

The System L1-type amino acid transporter mediates transport of large neutral amino acids (LNAA) in many mammalian cell-types. LNAA such as leucine are required for full activation of the mTOR-S6K signalling pathway promoting protein synthesis and cell growth. The SLC7A5 (LAT1) catalytic subunit of...

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Bibliographic Details
Main Authors: Nadège Poncet, Fiona E Mitchell, Adel F M Ibrahim, Victoria A McGuire, Grant English, J Simon C Arthur, Yun-Bo Shi, Peter M Taylor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3935884?pdf=render

Internet

http://europepmc.org/articles/PMC3935884?pdf=render

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