Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer

Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer

DUSP6/MKP3 is a dual-specific phosphatase that regulates extracellular regulated kinase ERK1/2 and ERK5 activity, with an increasingly recognized role as tumor suppressor. In silico studies from Gene expression Omnibus (GEO) and Cancer Genome atlas (TCGA) databases reveal poor prognosis in those Non...

Full description

Bibliographic Details
Main Authors: Verónica Moncho-Amor, Laura Pintado-Berninches, Inmaculada Ibañez de Cáceres, Ester Martín-Villar, Miguel Quintanilla, Probir Chakravarty, María Cortes-Sempere, Beatriz Fernández-Varas, Carlos Rodriguez-Antolín, Javier de Castro, Leandro Sastre, Rosario Perona
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:International Journal of Molecular Sciences
Subjects:
<i>DUSP6</i>
MKP3
tumor suppressor
ERK1/2
ERK5
tumorigenesis
EMT
Online Access:https://www.mdpi.com/1422-0067/20/8/2036

Internet

https://www.mdpi.com/1422-0067/20/8/2036

Similar Items