The Cyclooxigenase-2 Inhibitor Parecoxib Prevents Epidermal Dysplasia in HPV16-Transgenic Mice: Efficacy and Safety Observations

The Cyclooxigenase-2 Inhibitor Parecoxib Prevents Epidermal Dysplasia in HPV16-Transgenic Mice: Efficacy and Safety Observations

Carcinogenesis induced by high-risk human papillomavirus (HPV) involves inflammatory phenomena, partially mediated by cyclooxigenase-2. In pre-clinical models of HPV-induced cancer, cyclooxygenase-2 inhibitors have shown significant efficacy, but also considerable toxicity. This study addresses the...

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Bibliographic Details
Main Authors: Tiago Ferreira, Sandra Campos, Mónica G. Silva, Rita Ribeiro, Susana Santos, José Almeida, Maria João Pires, Rui Miguel Gil da Costa, Cláudia Córdova, António Nogueira, Maria João Neuparth, Rui Medeiros, Margarida Maria da Silva Monteiro Bastos, Isabel Gaivão, Francisco Peixoto, Maria Manuel Oliveira, Paula Alexandra Oliveira
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:International Journal of Molecular Sciences
Subjects:
COX-2
NSAID
in vivo
K14HPV16
Online Access:https://www.mdpi.com/1422-0067/20/16/3902

Internet

https://www.mdpi.com/1422-0067/20/16/3902

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