Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration

Abstract Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites, which are pathological hallmarks of Parkinson’s disease (PD). The contribution of αSyn to PD is well established, but the detailed mechanism remains obscure. Using a model in which αSyn aggregation in...

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Bibliographic Details
Main Authors: Xinhe Wang, Katelyn Becker, Nathan Levine, Michelle Zhang, Andrew P. Lieberman, Darren J. Moore, Jiyan Ma
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Acta Neuropathologica Communications
Subjects:
α-Synuclein
Aggregation
PFF
Mitochondria
Lewy body
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s40478-019-0696-4

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http://link.springer.com/article/10.1186/s40478-019-0696-4

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