Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration
Abstract Misfolded alpha-synuclein (αSyn) is a major constituent of Lewy bodies and Lewy neurites, which are pathological hallmarks of Parkinson’s disease (PD). The contribution of αSyn to PD is well established, but the detailed mechanism remains obscure. Using a model in which αSyn aggregation in...
Main Authors: | Xinhe Wang, Katelyn Becker, Nathan Levine, Michelle Zhang, Andrew P. Lieberman, Darren J. Moore, Jiyan Ma |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-03-01
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Series: | Acta Neuropathologica Communications |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s40478-019-0696-4 |
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