ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation

ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation

Abstract Background Adenosine deaminases acting on RNA (ADARs) are involved in adenosine-to-inosine (A-to-I) editing and implicated in tumorigenesis and prognosis. Emerging evidence has indicated that ADAR1, an ADAR family member, participates in the regulation of various cancers; however, its biolo...

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Bibliographic Details
Main Authors: Xue Liu, Yu Fu, Jiadong Huang, Meng Wu, Zhenxing Zhang, Rongyao Xu, Ping Zhang, Shouwei Zhao, Laikui Liu, Hongbing Jiang
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ADAR1
Oral squamous cell carcinoma
Dicer
microRNA
Epithelial-mesenchymal transition
Cancer stem cells
Online Access:http://link.springer.com/article/10.1186/s13046-019-1300-2

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http://link.springer.com/article/10.1186/s13046-019-1300-2

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