The kinase PDK1 is essential for B-cell receptor mediated survival signaling.

The kinase PDK1 is essential for B-cell receptor mediated survival signaling.

Phosphoinositide-dependent kinase 1 (PDK1) plays an important role in integrating the T cell antigen receptor (TCR) and CD28 signals to achieve efficient NF-κB activation. PDK1 is also an important regulator of T cell development, mediating pre-TCR induced proliferation signals. However, the role of...

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Bibliographic Details
Main Authors: Sung-Gyoo Park, Meixiao Long, Jung-Ah Kang, Woo-Seok Kim, Cho-Rong Lee, Sin-Hyeog Im, Ian Strickland, Jan Schulze-Luehrmann, Matthew S Hayden, Sankar Ghosh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3564844?pdf=render

Internet

http://europepmc.org/articles/PMC3564844?pdf=render

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