Bioavailability Improvement of Carbamazepine via Oral Administration of Modified-Release Amorphous Solid Dispersions in Rats

Bioavailability Improvement of Carbamazepine via Oral Administration of Modified-Release Amorphous Solid Dispersions in Rats

The purpose of this study was to improve the bioavailability of carbamazepine (CBZ), a poorly water-soluble antiepileptic drug, via modified-release amorphous solid dispersions (mr-ASD) by a thin film freezing (TFF) process. Three types of CBZ-mr-ASD with immediate-, delayed-, and controlled-release...

Full description

Bibliographic Details
Main Authors: Houli Li, Meimei Zhang, Lilong Xiong, Weiyi Feng, Robert O. Williams
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceutics
Subjects:
carbamazepine
amorphous solid dispersions
modified-release
oral administration
bioavailability
thin film freezing
Online Access:https://www.mdpi.com/1999-4923/12/11/1023

Internet

https://www.mdpi.com/1999-4923/12/11/1023

Similar Items