Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease

Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease

An in situ approach was used to identify the oxidized RNA nucleoside 8-hydroxyguanosine (8OHG) in the frontal cortex of familial Alzheimer's disease (FAD) with a mutation in presenilin-1 (PS-1) or amyloid β protein precursor (AβPP) gene (n = 13, age 47–81 years). Neurons with marked 8OHG immuno...

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Bibliographic Details
Main Authors: Akihiko Nunomura, Shigeru Chiba, Carol F. Lippa, Patrick Cras, Rajesh N. Kalaria, Atsushi Takeda, Kazuhiro Honda, Mark A. Smith, George Perry
Format: Article
Language:English
Published: Elsevier 2004-10-01
Series:Neurobiology of Disease
Subjects:
Amyloid β protein precursor
Familial Alzheimer's disease
8-Hydroxyguanosine
Oxidative stress
Presenilin
RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001329

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http://www.sciencedirect.com/science/article/pii/S0969996104001329

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