Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

Gut-Resident Lactobacillus Abundance Associates with IDO1 Inhibition and Th17 Dynamics in SIV-Infected Macaques

Gut microbes can profoundly modulate mucosal barrier-promoting Th17 cells in mammals. A salient feature of HIV/simian immunodeficiency virus (SIV) immunopathogenesis is the loss of Th17 cells, which has been linked to increased activity of the immunomodulatory enzyme, indoleamine 2,3-dioxygenase 1 (...

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Bibliographic Details
Main Authors: Ivan Vujkovic-Cvijin, Louise A. Swainson, Simon N. Chu, Alexandra M. Ortiz, Clark A. Santee, Annalise Petriello, Richard M. Dunham, Douglas W. Fadrosh, Din L. Lin, Ali A. Faruqi, Yong Huang, Cristian Apetrei, Ivona Pandrea, Frederick M. Hecht, Christopher D. Pilcher, Nichole R. Klatt, Jason M. Brenchley, Susan V. Lynch, Joseph M. McCune
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715011808

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http://www.sciencedirect.com/science/article/pii/S2211124715011808

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