Dexamethasone counteracts hepatic inflammation and oxidative stress in cholestatic rats via CAR activation.

Dexamethasone counteracts hepatic inflammation and oxidative stress in cholestatic rats via CAR activation.

Glucocorticoids (GCs) are currently used for the therapeutic management of cholestatic diseases, but their use and molecular mechanism remain controversial. The aims of this study were 1) to assess the therapeutic effect of a 2-week treatment with the GC dexamethasone on hepatic damage in bile duct-...

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Bibliographic Details
Main Authors: Daniela Gabbia, Luisa Pozzo, Giorgia Zigiotto, Marco Roverso, Diana Sacchi, Arianna Dalla Pozza, Maria Carrara, Sara Bogialli, Annarosa Floreani, Maria Guido, Sara De Martin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6155538?pdf=render

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http://europepmc.org/articles/PMC6155538?pdf=render

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