Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling

Breast Cancer-Derived Exosomes Alter Macrophage Polarization via gp130/STAT3 Signaling

Tumor-derived exosomes are being recognized as essential mediators of intercellular communication between cancer and immune cells. It is well established that bone marrow-derived macrophages (BMDMs) take up tumor-derived exosomes. However, the functional impact of these exosomes on macrophage phenot...

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Bibliographic Details
Main Authors: Sunyoung Ham, Luize G. Lima, Edna Pei Zhi Chai, Alexandra Muller, Richard J. Lobb, Sophie Krumeich, Shu Wen Wen, Adrian P. Wiegmans, Andreas Möller
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
cancer-derived exosomes
breast cancer
tumor-associated macrophages
glycoprotein 130
interleukin-6
STAT3
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00871/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00871/full

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