The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

The Ubiquitin Proteasome System Is a Key Regulator of Pluripotent Stem Cell Survival and Motor Neuron Differentiation

The ubiquitin proteasome system (UPS) plays an important role in regulating numerous cellular processes, and a dysfunctional UPS is thought to contribute to motor neuron disease. Consequently, we sought to map the changing ubiquitome in human iPSCs during their pluripotent stage and following differ...

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Bibliographic Details
Main Authors: Monique Bax, Jessie McKenna, Dzung Do-Ha, Claire H. Stevens, Sarah Higginbottom, Rachelle Balez, Mauricio e Castro Cabral-da-Silva, Natalie E. Farrawell, Martin Engel, Philip Poronnik, Justin J. Yerbury, Darren N. Saunders, Lezanne Ooi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
ubiquitin
ubiquitinomics
UBA1
induced pluripotent stem cell
motor neuron
motor neurone disease
amyotrophic lateral sclerosis
Online Access:https://www.mdpi.com/2073-4409/8/6/581

Internet

https://www.mdpi.com/2073-4409/8/6/581

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