Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation

Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation

Background/Aims: Recent studies provided compelling evidence that stimulation of the calcium sensing receptor (CaSR) exerts direct renoprotective action at the glomerular podocyte level. This protective action may be attributed to the RhoA-dependent stabilization of the actin cytoskeleton. However,...

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Bibliographic Details
Main Authors: Lei Zhang, Tianrong Ji, Qin Wang, Kexin Meng, Rui Zhang, He Yang, Chang Liao, Linlin Ma, Jundong Jiao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Trpc6
Calcium-sensing receptor
RhoA
Podocytes
Online Access:https://www.karger.com/Article/FullText/484064

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https://www.karger.com/Article/FullText/484064

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