Impairment of Spike-Timing-Dependent Plasticity at Schaffer Collateral-CA1 Synapses in Adult APP/PS1 Mice Depends on Proximity of Aβ Plaques

Impairment of Spike-Timing-Dependent Plasticity at Schaffer Collateral-CA1 Synapses in Adult APP/PS1 Mice Depends on Proximity of Aβ Plaques

Alzheimer’s disease (AD) is a multifaceted neurodegenerative disorder characterized by progressive and irreversible cognitive decline, with no disease-modifying therapy until today. Spike timing-dependent plasticity (STDP) is a Hebbian form of synaptic plasticity, and a strong candidate to underlie...

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Bibliographic Details
Main Authors: Machhindra Garad, Elke Edelmann, Volkmar Leßmann
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
adult animals
Alzheimer
timing-dependent LTP
Schaffer collateral-CA1 synapses
amyloid beta plaques
fingolimod
Online Access:https://www.mdpi.com/1422-0067/22/3/1378

Internet

https://www.mdpi.com/1422-0067/22/3/1378

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