Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice

Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice

We developed a biocompatible splenic vector for a DNA vaccine against melanoma. The splenic vector is a ternary complex composed of plasmid DNA (pDNA), biodegradable dendrigraft poly-L-lysine (DGL), and γ-polyglutamic acid (γ-PGA), the selective uptake of which by the spleen has already been demonst...

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Bibliographic Details
Main Authors: Yukinobu Kodama, Ayako Tokunaga, Junya Hashizume, Hiroo Nakagawa, Hitomi Harasawa, Tomoaki Kurosaki, Tadahiro Nakamura, Koyo Nishida, Mikiro Nakashima, Mitsuru Hashida, Shigeru Kawakami, Hitoshi Sasaki
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Drug Delivery
Subjects:
splenic vector
dna vaccine
ternary complex
melanoma
gene delivery
Online Access:http://dx.doi.org/10.1080/10717544.2021.1895904

Internet

http://dx.doi.org/10.1080/10717544.2021.1895904

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