Antiepileptic Drug Tiagabine Does Not Directly Target Key Cardiac Ion Channels Kv11.1, Nav1.5 and Cav1.2

Antiepileptic Drug Tiagabine Does Not Directly Target Key Cardiac Ion Channels Kv11.1, Nav1.5 and Cav1.2

Tiagabine is an antiepileptic drug used for the treatment of partial seizures in humans. Recently, this drug has been found useful in several non-epileptic conditions, including anxiety, chronic pain and sleep disorders. Since tachycardia—an impairment of cardiac rhythm due to cardiac ion channel dy...

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Bibliographic Details
Main Authors: Magdalena Kowalska, Łukasz Fijałkowski, Monika Kubacka, Kinga Sałat, Grzegorz Grześk, Jacek Nowaczyk, Alicja Nowaczyk
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
tiagabine
cardiac voltage-gated ion channels
molecular modeling
ECG study
Online Access:https://www.mdpi.com/1420-3049/26/12/3522

Internet

https://www.mdpi.com/1420-3049/26/12/3522

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