Association of Protective HLA-A With HLA-B∗27 Positive Ankylosing Spondylitis

Association of Protective HLA-A With HLA-B∗27 Positive Ankylosing Spondylitis

ObjectivesTo further elucidate the role of the MHC in ankylosing spondylitis by typing 17 genes, searching for HLA-B∗27 independent associations and assessing the impact of sex on this male biased disease.MethodsHigh-confidence two-field resolution genotyping was performed on 310 cases and 2196 cont...

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Bibliographic Details
Main Authors: Jessika Nordin, Mats Pettersson, Lina Hultin Rosenberg, Argyri Mathioudaki, Åsa Karlsson, Eva Murén, Karolina Tandre, Lars Rönnblom, Alf Kastbom, Jan Cedergren, Per Eriksson, Peter Söderkvist, Kerstin Lindblad-Toh, Jennifer R. S. Meadows
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Genetics
Subjects:
ankylosing spondylitis
HLA-B∗27 positive
HLA-A∗24:02
sex biased
major histocompatibility complex
HLA allele typing
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.659042/full

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https://www.frontiersin.org/articles/10.3389/fgene.2021.659042/full

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