Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.

Severe thymic atrophy in a mouse model of skin inflammation accounts for impaired TNFR1 signaling.

Transgenic mice expressing the caspase-cleaved form of the tyrosine kinase Lyn (LynΔN) develop a TNFα-dependent skin disease that accurately recapitulates human psoriasis. Participation of lymphocytes in this disease was confirmed by backcrossing LynΔN mice on a Rag-1 deficient background. The prese...

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Main Authors: Nathalie Belhacéne, Parvati Gamas, Diogo Gonçalvès, Marie Jacquin, Marie Beneteau, Arnaud Jacquel, Pascal Colosetti, Jean-Ehrland Ricci, Abdellilah Wakkach, Patrick Auberger, Sandrine Marchetti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071785/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23071785/?tool=EBI

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