Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease

Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease

Apolipoprotein E4 (APOE4) allele is a major risk factor for late-onset familial and sporadic Alzheimer disease (AD). The mechanism of action of APOE in the etiology of AD remains unclear. Using gene expression (microarray) analysis of human hippocampus from APOE3/3 AD and APOE4/4 AD cases, we found...

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Bibliographic Details
Main Authors: Pu-Ting Xu, Yi-Ju Li, Xue-Jun Qin, Clemens R. Scherzer, Hong Xu, Donald E. Schmechel, Christine M. Hulette, John Ervin, Steven R. Gullans, Jonathan Haines, Margaret A. Pericak-Vance, John R. Gilbert
Format: Article
Language:English
Published: Elsevier 2006-02-01
Series:Neurobiology of Disease
Subjects:
Apolipoprotein E
Alzheimer disease
Gene expression
Microarray
Apoptosis
Signal pathways
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002032

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http://www.sciencedirect.com/science/article/pii/S0969996105002032

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