Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion

Cerebrospinal Fluid TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Patients with and without the C9ORF72 Hexanucleotide Expansion

Background: TDP-43 is the main protein component of ubiquitinated inclusions in a subgroup of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) patients. The C9ORF72 hexanucleotide expansion is one of the main mutations associated with TDP-43 pathology in FTLD and ALS....

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Bibliographic Details
Main Authors: Anna Junttila, Mari Kuvaja, Päivi Hartikainen, Maritta Siloaho, Seppo Helisalmi, Virpi Moilanen, Anna Kiviharju, Lilja Jansson, Pentti J. Tienari, Anne Marja Remes, Sanna-Kaisa Herukka
Format: Article
Language:English
Published: Karger Publishers 2016-04-01
Series:Dementia and Geriatric Cognitive Disorders Extra
Subjects:
Frontotemporal lobar degeneration
Frontotemporal dementia
Amyotrophic lateral sclerosis
TDP-43
Cerebrospinal fluid
C9ORF72
Biomarker
ELISA
Online Access:http://www.karger.com/Article/FullText/444788

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http://www.karger.com/Article/FullText/444788

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