Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex

Sporozoite neutralizing antibodies elicited in mice and rhesus macaques immunized with a Plasmodium falciparum repeat peptide conjugated to meningococcal outer membrane protein complex

Antibodies that neutralize infectivity of malaria sporozoites target the central repeat region of the circumsporozoite (CS) protein, which in Plasmodium falciparum is comprised primarily of 30-40 tandem NANP tetramer repeats. We evaluated immunogenicity of an alum-adsorbed (NANP)6 peptide conjugate...

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Bibliographic Details
Main Authors: Craig ePrzysiecki, Bob eLucas, Robert eMitchell, Zhiyun eWen, Daniel eCarapau, Xin-Min eWang, Debbie eNahas, Chengwei eWu, Robert eHepler, Elizabeth eOttinger, Jan eter Meulen, David eKaslow, John eShiver, Hui eXu, Elizabeth eNardin
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Mice
Sporozoites
Vaccine
antibody
Rhesus
P. falciparum
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00146/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcimb.2012.00146/full

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