Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m
The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 a...
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Serbian Chemical Society
2006-01-01
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doaj-fb5fe79a60274454ad6e926f536765b02020-12-24T14:30:00ZengSerbian Chemical Society Journal of the Serbian Chemical Society0352-51391820-74212006-01-01711556510.2298/JSC0601055B0352-51390601055BAcid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99mBrborić Jasmina S.0Jovanović Mirjana S.1Popović Gordana V.2Kapetanović Vera P.3Vladimirov Sote M.4Farmaceutski fakultet, BeogradInstitut za nuklearne nauke „Vinča', Laboratorija za radioizotope, BeogradFarmaceutski fakultet, BeogradFarmaceutski fakultet, BeogradFarmaceutski fakultet, BeogradThe acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 and pK4 = 10.9 ± 0.1. The determinations were performed at 25 ºC and an ionic strength of 0.1 mol/dm3 (NaCl). The acidity constants (pK1 = 1.3 ± 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 ºC and an ionic strength 1 mol/dm3 (HCl, NaCl). DIIODIDA was labeled with technetium-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity (>98 %).http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390601055B.pdfiminodiacetic acid analoguesacidity constantshepatobiliary agenttechnetium-99m |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brborić Jasmina S. Jovanović Mirjana S. Popović Gordana V. Kapetanović Vera P. Vladimirov Sote M. |
spellingShingle |
Brborić Jasmina S. Jovanović Mirjana S. Popović Gordana V. Kapetanović Vera P. Vladimirov Sote M. Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m Journal of the Serbian Chemical Society iminodiacetic acid analogues acidity constants hepatobiliary agent technetium-99m |
author_facet |
Brborić Jasmina S. Jovanović Mirjana S. Popović Gordana V. Kapetanović Vera P. Vladimirov Sote M. |
author_sort |
Brborić Jasmina S. |
title |
Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m |
title_short |
Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m |
title_full |
Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m |
title_fullStr |
Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m |
title_full_unstemmed |
Acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m |
title_sort |
acid-base equilibria of 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid and its labeling with technetium-99m |
publisher |
Serbian Chemical Society |
series |
Journal of the Serbian Chemical Society |
issn |
0352-5139 1820-7421 |
publishDate |
2006-01-01 |
description |
The acid-base equilibria of a novel hepatobiliary imaging agent, 2,4-diiodo-6-methylphenylcarbamoylmethyl iminodiacetic acid (DIIODIDA) were studied. The potentiometrically determined acidity constants of the second carboxylic group, amino and amide groups were pK2 = 2.52 ± 0.02; pK3 = 5.86 ± 0.06 and pK4 = 10.9 ± 0.1. The determinations were performed at 25 ºC and an ionic strength of 0.1 mol/dm3 (NaCl). The acidity constants (pK1 = 1.3 ± 0.4) corresponding to the first carboxylic group was determined indirectly, on the basis of equilibrium constants obtained in a heterogeneous system, at 25 ºC and an ionic strength 1 mol/dm3 (HCl, NaCl). DIIODIDA was labeled with technetium-99m, and the influence of pH on the yield of labeling was investigated. It was found that labeling within the pH range from 5.5 to 6.5 provided a radiopharmaceutical of high radiochemical purity (>98 %). |
topic |
iminodiacetic acid analogues acidity constants hepatobiliary agent technetium-99m |
url |
http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390601055B.pdf |
work_keys_str_mv |
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