Intracytoplasmic sperm injection using DNA-fragmented sperm in mice negatively affects embryo-derived embryonic stem cells, reduces the fertility of male offspring and induces heritable changes in epialleles.

Intracytoplasmic sperm injection using DNA-fragmented sperm in mice negatively affects embryo-derived embryonic stem cells, reduces the fertility of male offspring and induces heritable changes in epialleles.

Intracytoplasmic sperm injection (ICSI) in mice using DNA-fragmented sperm (DFS) has been linked to an increased risk of genetic and epigenetic abnormalities both in embryos and offspring. This study examines: whether embryonic stem cells (ESCs) derived from DFS-ICSI embryos reflect the abnormalitie...

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Bibliographic Details
Main Authors: Priscila Ramos-Ibeas, Alexandra Calle, Raúl Fernández-González, Ricardo Laguna-Barraza, Eva Pericuesta, Antonia Calero, Miguel Ángel Ramírez, Alfonso Gutiérrez-Adán
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3990723?pdf=render

Internet

http://europepmc.org/articles/PMC3990723?pdf=render

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