4′,6-Dihydroxy-4-methoxyisoaurone inhibits TNF-α-induced NF-κB activation and expressions of NF-κB-regulated target gene products

4′,6-Dihydroxy-4-methoxyisoaurone inhibits TNF-α-induced NF-κB activation and expressions of NF-κB-regulated target gene products

The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, apoptosis, and angiogenesis. In our search for NF-κB inhibitors from natural resources, we identified 4′,6-dihydroxy-4-methoxyisoaurone (ISOA) as an inhibitor of NF-κB activation from the...

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Bibliographic Details
Main Authors: Juan Ma, Chunliu Mi, Ke Si Wang, Jung Joon Lee, Xuejun Jin
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Journal of Pharmacological Sciences
Subjects:
4′,6-dihydroxy-4-methoxyisoaurone
NF-κB
IκBα
p65
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861315002066

Internet

http://www.sciencedirect.com/science/article/pii/S1347861315002066

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