Peperomin E Induces Promoter Hypomethylation of Metastatic-Suppressor Genes and Attenuates Metastasis in Poorly Differentiated Gastric Cancer

Peperomin E Induces Promoter Hypomethylation of Metastatic-Suppressor Genes and Attenuates Metastasis in Poorly Differentiated Gastric Cancer

Background/Aims: Peperomin E (PepE), a natural secolignan isolated from the whole plant of Peperomia dindygulensis, has been reported by ourselves and others to display potent anti-cancer effects in many types cancer cells, especially gastric cancer. However, the effects of PepE on the metastasis of...

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Bibliographic Details
Main Authors: Xin-zhi  Wanga, Jia-li Gu, Ming Gao, Yong Bian, Jiang-yu Liang, Hong-mei Wen, Hao Wu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Peperomin E
Gastric cancer
Metastasis
DNA methyltranferase inhibition
AMPKα-Sp1 signaling
Metastatic-suppressor gene
Online Access:https://www.karger.com/Article/FullText/495096

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https://www.karger.com/Article/FullText/495096

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