Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation.

Protein isoaspartate methyltransferase prevents apoptosis induced by oxidative stress in endothelial cells: role of Bcl-Xl deamidation and methylation.

BACKGROUND:Natural proteins undergo in vivo spontaneous post-biosynthetic deamidation of specific asparagine residues with isoaspartyl formation. Deamidated-isomerized molecules are both structurally and functionally altered. The enzyme isoaspartyl protein carboxyl-O-methyltransferase (PCMT; EC 2.1....

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Main Authors: Amelia Cimmino, Rosanna Capasso, Fabbri Muller, Irene Sambri, Lucia Masella, Marianna Raimo, Maria Luigia De Bonis, Stefania D'Angelo, Vincenzo Zappia, Patrizia Galletti, Diego Ingrosso
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2532751?pdf=render

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http://europepmc.org/articles/PMC2532751?pdf=render

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