DL0410 Ameliorates Memory and Cognitive Impairments Induced by Scopolamine via Increasing Cholinergic Neurotransmission in Mice

Deficiency of the cholinergic system is thought to play a vital role in cognitive impairment of dementia. DL0410 was discovered as a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinestease (BuChE), with potent efficiency in in-vitro experiments, but its in vivo effect on the cholinerg...

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Bibliographic Details
Main Authors: Wenwen Lian, Jiansong Fang, Lvjie Xu, Wei Zhou, De Kang, Wandi Xiong, Hao Jia, Ai-Lin Liu, Guan-Hua Du
Format: Article
Language:English
Published: MDPI AG 2017-03-01
Series:Molecules
Subjects:
ACh
Online Access:http://www.mdpi.com/1420-3049/22/3/410