Removal of a Subset of Non-essential Genes Fully Attenuates a Highly Virulent Mycoplasma Strain

Removal of a Subset of Non-essential Genes Fully Attenuates a Highly Virulent Mycoplasma Strain

Mycoplasmas are the smallest free-living organisms and cause a number of economically important diseases affecting humans, animals, insects, and plants. Here, we demonstrate that highly virulent Mycoplasma mycoides subspecies capri (Mmc) can be fully attenuated via targeted deletion of non-essential...

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Bibliographic Details
Main Authors: Joerg Jores, Li Ma, Paul Ssajjakambwe, Elise Schieck, Anne Liljander, Suchismita Chandran, Michael H. Stoffel, Valentina Cippa, Yonathan Arfi, Nacyra Assad-Garcia, Laurent Falquet, Pascal Sirand-Pugnet, Alain Blanchard, Carole Lartigue, Horst Posthaus, Fabien Labroussaa, Sanjay Vashee
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Microbiology
Subjects:
Mycoplasma mycoides subsp. capri
attenuation
genome engineering
in vivo challenge
virulence traits
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00664/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.00664/full

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