Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

Integrated analysis of Xist upregulation and X-chromosome inactivation with single-cell and single-allele resolution

X-chromosome inactivation (XCI) ensures dosage compensation between the sexes. Here the authors perform allele-specific single-cell RNA sequencing in differentiating mouse embryonic stem cells to provide a detailed profile of the onset of XCI.

Bibliographic Details
Main Authors: Guido Pacini, Ilona Dunkel, Norbert Mages, Verena Mutzel, Bernd Timmermann, Annalisa Marsico, Edda G. Schulz
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-23643-6

Internet

https://doi.org/10.1038/s41467-021-23643-6

Similar Items