Redox controls RecA protein activity via reversible oxidation of its methionine residues

Redox controls RecA protein activity via reversible oxidation of its methionine residues

Reactive oxygen species (ROS) cause damage to DNA and proteins. Here, we report that the RecA recombinase is itself oxidized by ROS. Genetic and biochemical analyses revealed that oxidation of RecA altered its DNA repair and DNA recombination activities. Mass spectrometry analysis showed that exposu...

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Bibliographic Details
Main Authors: Camille Henry, Laurent Loiseau, Alexandra Vergnes, Didier Vertommen, Angela Mérida-Floriano, Sindhu Chitteni-Pattu, Elizabeth A Wood, Josep Casadesús, Michael M Cox, Frédéric Barras, Benjamin Ezraty
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
oxidative damage
methionine sulfoxide
RecA
redox
Online Access:https://elifesciences.org/articles/63747

Internet

https://elifesciences.org/articles/63747

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